CVE-2025-12921HIGH 8.8EPSS p36.5%

CVE-2025-12921CVE-2025-12921

Description

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

Scoring

CVSS 3.18.8 (HIGH)
VectorCVSS:3.1/AV:N/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H
EPSS0.46% probability of exploitation · percentile 36.5% · 2026-06-18T12:00:27Z
Published2025-11-10
Last modified2026-04-29

Underlying weaknesses· 2

CWE-74CWE-91

References

  1. https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md
  2. https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#poc
  3. https://vuldb.com/?ctiid.331641
  4. https://vuldb.com/?id.331641
  5. https://vuldb.com/?submit.680872
  6. https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md
  7. https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#poc

2

TypeTargetConfidenceTier
WeaknessImproper Neutralization of Special Elements in Output Used by a Downstream Component ('Injection')cwe-740%live
WeaknessXML Injection (aka Blind XPath Injection)cwe-910%live

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Sourced from NVD + FIRST.org EPSS. Curated for EU compliance use cases by Adam Lundqvist, Founder at SQUR.